2020-current
Single-cell mtDNA dynamics in tumors is driven by coregulation of nuclear and mitochondrial genomesMinsoo K, Gorelick AN, Vazquez-Garcia I, Williams MJ, Salehi S, Shi H, Weiner AC, Ceglia N, Funnell T, Park T, Park T, Boscenco S, O'Flanagan CH, Jiang H, Grewal D, Tang C, Rusk N, Gammage PA, McPherson A, Aparicio S, Shah SP, Reznik E
Obesity shapes selection for driver mutations in cancerTang C, Castillon VJ, Waters M Fong C, Park T, Boscenco S, Kim S, Schultz N, Ostrovnaya I, Gusev A, Jee J, Reznik E
Nature Genetics
(in press)
Mitochondrial DNA mutations drive aerobic glycolysis to enhance checkpoint blockade response in melanomaMahmood M, Liu EM, Shergold AL, Tolla E, Tait-Mulder J, Huerta-Uribe A, Shokry E, Young AL, Lilla S, Kim M, Park T, Boscenco S, Manchon JL, Rodríguez-Antona C, Walters RC, Springett RJ, Blaza JN, Mitchell L, Blyth K, Zanivan S, Sumpton D, Roberts EW, Reznik E, Gammage PA
Immunometabolic coevolution defines unique microenvironmental niches in ccRCCTang C, Xie AX, Liu EM, Kuo F, Kim M, DiNatale RG, Golkaram M, Chen YB, Gupta S, Motzer RJ, Russo P, Coleman JA, Carlo MI, Voss MH, Kotecha RR, Lee CH, Tansey W, Schultz N, Hakimi AA, Reznik E
A multimodal atlas of tumour metabolism reveals the architecture of gene–metabolite covariationBenedetti E, Liu EM, Tang C, Kuo F, Buyukozkan M, Park T, Park J, Correa F, Hakimi AA, Intlekofer AM, Krumsiek J, Reznik E
Nature Metabolism
5: 1029–1044 (2023)
Spatiotemporal evolution of the clear cell renal cell carcinoma microenvironment links intra-tumoral heterogeneity to immune escapeGolkaram M, Kuo F, Gupta S, Carlo MI, Salmans ML, Vijayaraghavan R, Tang C, Makarov V, Rappold P, Blum KA, Zhao C, Mehio R, Zhang S, Godsey J, Pawlowski T, DiNatale RG, Morris LGT, Durack J, Russo P, Kotecha RR, Coleman JA, Chen YB, Reuter VE, Motzer RJ, Voss MH, Liu L, Reznik E, Chan TA, Hakimi AA
Genome Medicine
14 (1)
: 143 (2022)
Mitonuclear Genotype Remodels the Metabolic and Microenvironmental Landscape of Hurthle Cell CarcinomaGanly I, Liu EM, Kuo F, Makarov V, Dong Y, Park J, Gong Y, Gorelick AN, Knauf JA, Benedetti E, Tait-Mulder J, Morris LGT, Fagin JA, Intlekofer AM, Krumsiek J, Gammage PA, Ghossein R, Xu B, Chan TA, Reznik E
Science Advances
8 (25)
: eabn9699 (2022)
Molecular Characterization of the Tumor Microenvironment in Renal Medullary CarcinomaTourigny DS, Zucker M, Kim M, Russo P, Coleman JA, Lee CH, Carlo MI, Chen Y, Hakimi AA, Kotecha RR, Reznik E
Frontiers in Oncology
12
(2022)
Genomic and Metabolic Hallmarks of SDHand FH-Deficient Renal Cell CarcinomasYoo A, Tang C, Zucker M, Fitzgerald K, DiNatale RG, Rappold PM, Weiss K, Freeman BA, Lee CH, Schultz N, Motzer R, Russo P, Coleman J, Reuter VE, Chen YB, Carlo MI, Gill AJ, Kotecha RR, Hakimi AA, Reznik E
European Urology Focus
S2405-4569 (21)
: 312-316 (2022)
Resource-efficient pooled sequencing expands translational impact in solid tumorsDiNatale RG, Mano R, Makarov V, Rusk N, Drill E, Winer A, Sankin A, Yoo A, Freeman BA, Hsieh JJ, Chen Y-B, Coleman JA, Berger M, Ostrovnaya I, Chan TA, Russo P, Reznik E, Hakimi AA
Kidney Cancer J.
19 (2)
: 18-23 (2021)
Phase and context shape the function of composite oncogenic mutationsGorelick AN, Sánchez-Rivera FJ, Cai Y, Bielski CM, Biederstedt E, Jonsson P, Richards AL, Vasan N, Penson AV, Friedman ND, Ho Y-J, Baslan T, Bandlamudi C, Scaltriti M, Schultz N, Lowe SW, Reznik E, Taylor BS
Nature
582 (7810)
: 100-103 (2020)
Comprehensive Genomic Analysis of Translocation Renal Cell Carcinoma Reveals Copy-Number Variations as Drivers of Disease ProgressionMarcon J, DiNatale RG, Sanchez A, Kotecha RR, Gupta S, Kuo F, Makarov V, Sandhu A, Mano R, Silagy AW, Blum KA, Nassau DE, Benfante NE, Ortiz MV, Carlo MI, Chan TA, Motzer RJ, Voss MH, Coleman JA, Russo P, Reuter VE, Hakimi AA, Reznik E
Clinical Cancer Research
26 (14)
: 3629-3640 (2020)
2015-2019
Abnormal oxidative metabolism in a quiet genomic background underlies clear cell papillary renal cell carcinomaXu J, Reznik E, Lee H-J, Gundem G, Jonsson P, Sarungbam J, Bialik A, Sanchez-Vega F, Creighton CJ, Hoekstra J, Zhang L, Sajjakulnukit P, Kremer D, Tolstyka Z, Casuscelli J, Stirdivant S, Tang J, Schultz N, Jeng P, Dong Y, Su W, Cheng EH, Russo P, Coleman JA, Papaemmanuil E, Chen Y-B, Reuter VE, Sander C, Kennedy SR, Hsieh JJ, Lyssiotis CA, Tickoo SK, Hakimi AA
Outcome and molecular characteristics of non-invasive encapsulated follicular variant of papillary thyroid carcinoma with oncocytic featuresXu B, Reznik E, Tuttle RM, Knauf J, Fagin JA, Katabi N, Dogan S, Aleynick N, Seshan V, Middha S, Enepekides D, Casadei GP, Solaroli E,Tallini G, Ghossein R, Ganly I
Endocrine
64 (1)
: 97-108 (2019)
Comparative Genomic Profiling of Matched Primary and Metastatic Tumors in Renal Cell CarcinomaBecerra MF, Reznik E, Redzematovic A, Tennenbaum DM, Kashan M, Ghanaat M, Casuscelli J, Manley B, Jonsson P, DiNatale RG, Blum KA, Durack JC, Solomon SB, Arcila ME, Bourque C, Socci N, Carlo MI, Lee CH, Voss MH, Feldman DR, Motzer RJ, Coleman JA, Russo P, Cheng EH, Hakimi AA, Hsieh JJ
European Urology Focus
4( 6)
: 986-994 (2017)
An Integrated Metabolic Atlas of Clear Cell Renal Cell CarcinomaHakimi AA, Reznik E, Lee C-H, Creighton CJ, Brannon AR, Luna A, Aksoy BA, Liu EM, Shen R, Lee W, Chen Y, Stirdivant SM, Russo P,Chen Y-B, Tickoo SK, Reuter VE, Cheng EH, Sander C, Hsieh JJ
Cancer Cell
29 (1)
: 104-116 (2016)
Mitochondrial DNA copy number variation across human cancersReznik E, Miller ML, Şenbabaoğlu Y, Riaz N, Sarungbam J, Tickoo SK, Al-Ahmadie HA, Lee W, Seshan VE, Hakimi AA, Sander C