PUBLICATIONS

Lead/Senior Author Publications

2020-current2015-20192010-2013

All Publications

GOOGLE SCHOLAR

Lead/Senior Author Publications

2020-current

Mitochondrial DNA mutations drive aerobic glycolysis to enhance checkpoint blockade response in melanoma
Mahmood M, Liu EM, Shergold AL, Tolla E, Tait-Mulder J, Huerta-Uribe A, Shokry E, Young AL, Lilla S, Kim M, Park T, Boscenco S, Manchon JL, Rodríguez-Antona C, Walters RC, Springett RJ, Blaza JN, Mitchell L, Blyth K, Zanivan S, Sumpton D, Roberts EW, Reznik E, Gammage PA
Nature Cancer
(2024)
Immunometabolic coevolution defines unique microenvironmental niches in ccRCC
Tang C, Xie AX, Liu EM, Kuo F, Kim M, DiNatale RG, Golkaram M, Chen YB, Gupta S, Motzer RJ, Russo P, Coleman JA, Carlo MI, Voss MH, Kotecha RR, Lee CH, Tansey W, Schultz N, Hakimi AA, Reznik E
Cell Metabolism
(2023)
A multimodal atlas of tumour metabolism reveals the architecture of gene–metabolite covariation
Benedetti E, Liu EM, Tang C, Kuo F, Buyukozkan M, Park T, Park J, Correa F, Hakimi AA, Intlekofer AM, Krumsiek J, Reznik E
Nature Metabolism
5: 1029–1044 (2023)
Spatiotemporal evolution of the clear cell renal cell carcinoma microenvironment links intra-tumoral heterogeneity to immune escape
Golkaram M, Kuo F, Gupta S, Carlo MI, Salmans ML, Vijayaraghavan R, Tang C, Makarov V, Rappold P, Blum KA, Zhao C, Mehio R, Zhang S, Godsey J, Pawlowski T, DiNatale RG, Morris LGT, Durack J, Russo P, Kotecha RR, Coleman JA, Chen YB, Reuter VE, Motzer RJ, Voss MH, Liu L, Reznik E, Chan TA, Hakimi AA
Genome Medicine
14 (1)
: 143 (2022)
MIRTH: Metabolite Imputation via Rank-Transformation and Harmonization
Freeman BA, Jaro S, Park T, Keene S, Tansey W, Reznik E
Genome Biology
23 (1)
: 184 (2022)
Mitochondrial DNA is a major source of driver mutations in cancer
Kim M, Mahmood M, Reznik E, Gammage PA
Trends Cancer
S2405-8033 (22)
: 172-178 (2022)
Mitonuclear Genotype Remodels the Metabolic and Microenvironmental Landscape of Hurthle Cell Carcinoma
Ganly I, Liu EM, Kuo F, Makarov V, Dong Y, Park J, Gong Y, Gorelick AN, Knauf JA, Benedetti E, Tait-Mulder J, Morris LGT, Fagin JA, Intlekofer AM, Krumsiek J, Gammage PA, Ghossein R, Xu B, Chan TA, Reznik E
Science Advances
8 (25)
: eabn9699 (2022)
Molecular Characterization of the Tumor Microenvironment in Renal Medullary Carcinoma
Tourigny DS, Zucker M, Kim M, Russo P, Coleman JA, Lee CH, Carlo MI, Chen Y, Hakimi AA, Kotecha RR, Reznik E
Frontiers in Oncology
12
 (2022)
Genomic and Metabolic Hallmarks of SDHand FH-Deficient Renal Cell Carcinomas
Yoo A, Tang C, Zucker M, Fitzgerald K, DiNatale RG, Rappold PM, Weiss K, Freeman BA, Lee CH, Schultz N, Motzer R, Russo P, Coleman J, Reuter VE, Chen YB, Carlo MI, Gill AJ, Kotecha RR, Hakimi AA, Reznik E
European Urology Focus
S2405-4569 (21)
: 312-316 (2022)
Resource-efficient pooled sequencing expands translational impact in solid tumors
DiNatale RG, Mano R, Makarov V, Rusk N, Drill E, Winer A, Sankin A, Yoo A, Freeman BA, Hsieh JJ, Chen Y-B, Coleman JA, Berger M, Ostrovnaya I, Chan TA, Russo P, Reznik E, Hakimi AA
Kidney Cancer J.
19 (2)
: 18-23 (2021)
Respiratory complex and tissue lineage drive recurrent mutations in tumour mtDNA
Gorelick AN, Kim M, Chatila WK, La K, Hakimi AA, Berger MF, Taylor BS, Gammage PA, Reznik E
Nature Metabolism
3
: 558-570 (2021)
Chemerin Tips the Scales in ccRCC to Evade Ferroptosis
Reznik E, Jiang H, Hakimi AA
Cancer Discovery
11 (8)
: 1879-1880 (2021)
Phase and context shape the function of composite oncogenic mutations
Gorelick AN, Sánchez-Rivera FJ, Cai Y, Bielski CM, Biederstedt E, Jonsson P, Richards AL, Vasan N, Penson AV, Friedman ND, Ho Y-J, Baslan T, Bandlamudi C, Scaltriti M, Schultz N, Lowe SW, Reznik E, Taylor BS
Nature
582 (7810)
: 100-103 (2020)
Comprehensive Genomic Analysis of Translocation Renal Cell Carcinoma Reveals Copy-Number Variations as Drivers of Disease Progression
Marcon J, DiNatale RG, Sanchez A, Kotecha RR, Gupta S, Kuo F, Makarov V, Sandhu A, Mano R, Silagy AW, Blum KA, Nassau DE, Benfante NE, Ortiz MV, Carlo MI, Chan TA, Motzer RJ, Voss MH, Coleman JA, Russo P, Reuter VE, Hakimi AA, Reznik E
Clinical Cancer Research
26 (14)
: 3629-3640 (2020)

2015-2019

Abnormal oxidative metabolism in a quiet genomic background underlies clear cell papillary renal cell carcinoma
Xu J, Reznik E, Lee H-J, Gundem G, Jonsson P, Sarungbam J, Bialik A, Sanchez-Vega F, Creighton CJ, Hoekstra J, Zhang L, Sajjakulnukit P, Kremer D, Tolstyka Z, Casuscelli J, Stirdivant S, Tang J, Schultz N, Jeng P, Dong Y, Su W, Cheng EH, Russo P, Coleman JA, Papaemmanuil E, Chen Y-B, Reuter VE, Sander C, Kennedy SR, Hsieh JJ, Lyssiotis CA, Tickoo SK, Hakimi AA
eLife
8
: e38986 (2019)
Metabolomics Informs Common Patterns of Molecular Dysfunction Across Histologies of Renal Cell Carcinoma
DiNatale RG, Sanchez A, Hakimi AA, Reznik E
Urologic Oncology: Seminars and Investigations
38 (10)
: 755-762 (2019)
Outcome and molecular characteristics of non-invasive encapsulated follicular variant of papillary thyroid carcinoma with oncocytic features
Xu B, Reznik E, Tuttle RM, Knauf J, Fagin JA, Katabi N, Dogan S, Aleynick N, Seshan V,  Middha S, Enepekides D, Casadei GP, Solaroli E,Tallini G, Ghossein R, Ganly I
Endocrine
64 (1)
: 97-108 (2019)
A Landscape of Metabolic Variation across Tumor Types
Reznik E, Luna A, Aksoy BA, Liu EM, La K, Ostrovnaya I, Creighton CJ, Hakimi AA, Sander C
Cell Systems
6 (3)
: 301-313 (2018)
Comparative Genomic Profiling of Matched Primary and Metastatic Tumors in Renal Cell Carcinoma
Becerra MF, Reznik E, Redzematovic A, Tennenbaum DM, Kashan M, Ghanaat M, Casuscelli J, Manley B, Jonsson P, DiNatale RG, Blum KA, Durack JC, Solomon SB, Arcila ME, Bourque C, Socci N, Carlo MI, Lee CH, Voss MH, Feldman DR, Motzer RJ, Coleman JA, Russo P, Cheng EH, Hakimi AA, Hsieh JJ
European Urology Focus
4( 6)
: 986-994 (2017)
Genome-Scale Architecture of Small Molecule Regulatory Networks and the Fundamental Trade-Off between Regulation and Enzymatic Activity
Reznik E, Christodoulou D, Goldford JE, Briars E, Sauer U, Segrè D, Noor E
Cell Reports
20 (11)
: 2666-2677 (2017)
Mitochondrial respiratory gene expression is suppressed in many cancers
Reznik E, Wang Q, La K, Schultz N, Sander C
eLife
6
: e21592 (2017)
An Integrated Metabolic Atlas of Clear Cell Renal Cell Carcinoma
Hakimi AA, Reznik E, Lee C-H, Creighton CJ, Brannon AR, Luna A, Aksoy BA, Liu EM, Shen R, Lee W, Chen Y, Stirdivant SM, Russo P,Chen Y-B, Tickoo SK, Reuter VE, Cheng EH, Sander C, Hsieh JJ
Cancer Cell
29 (1)
: 104-116 (2016)
Mitochondrial DNA copy number variation across human cancers
Reznik E, Miller ML, Şenbabaoğlu Y, Riaz N, Sarungbam J, Tickoo SK, Al-Ahmadie HA, Lee W, Seshan VE, Hakimi AA, Sander C
eLife
5
: e10769 (2016)
Extensive Decoupling of Metabolic Genes in Cancer
Reznik E, Sander C
PLOS Computational Biology
11 (5)
: e1004176 (2015)

2010-2013

The Average Enzyme Principle
Reznik E, Chaudhary O, Segrè D
FEBS Letters
587 (17)
: 2891-2894 (2013)
Flux Imbalance Analysis and the Sensitivity of Cellular Growth to Changes in Metabolite Pools
Reznik E, Mehta P, Segrè D
PLOS Computational Biology
9 (8)
: e1003195 (2013)
The Stubborn Roots of Metabolic Cycles
Reznik E, Watson A, Chaudhary O
Journal of the Royal Society Interface
10 (83)
: e20130087 (2013)
Invariance and Optimality in the Regulation of an Enzyme
Reznik E, Yohe S, Segrè D
Biology Direct
8
: 7 (2013)
The Dynamics of Hybrid Metabolic-Genetic Oscillators
Reznik E, Kaper TJ, Segrè D
Chaos
23 (1)
: e013132 (2013)
Temporal Expression-based Analysis of Metabolism
Collins SB, Reznik E, Segrè D
PLOS Computational Biology
8 (11)
: e1002781 (2012)
On the Stability of Metabolic Cycles
Reznik E, Segrè D
Journal of Theoretical Biology
266 (4)
: 536-549 (2010)